姓名:饶毅

职称:教授

职务和曾任重要职务

饶毅现任首都医科大学校长、北京大学讲席教授、北京脑科学与类脑研究中心创始主任、北京大学麦戈文脑研究所创始所长、北京大学-清华大学生命科学联合中心创始主任、北京大学校务委员会副主任，曾任北京大学理学部部长、生命科学学院院长。参与过中国多个科学和教育机构的改革和新建。西湖大学的共同发起者之一、并曾兼任其基础医学研究所所长。协助中国科学院在上海成立神经科学研究所（1999）、共同组建中国科学院上海交叉学科研究中心（2002）、参与建立北京生命科学研究所（2004）。中国“未来科学大奖”发起科学家之一（2016），“科学探索奖”的共同发起者（2018）。2018年起出任加拿大Gairdner国际医学大奖医学委员会成员。1994年至2007年，任教于美国圣路易斯的华盛顿大学和芝加哥的西北大学医学院。

研究领域

研究行为和认知的分子机理。提出化学连接组（CCT）的概念（涵盖同一动物中所有的神经递质、神经调质、神经肽及其受体）。发明化学连接组学的途径，制备必需的遗传工具，研究CCT中基因和细胞的功能作用、操纵化学传递、揭示神经环路。在人类，用遗传学、基因组学和功能性核磁共振研究认知重要的基因和脑区。研究对象包括果蝇、蛙、小鼠、大鼠、猴、人，以理解动物中普遍存在的和人特有的基本原理。

代表性论文：

1. Yi Rao, The First Hormone: Adrenaline. Trends in Endocrinology & Metabolism. 2019, 30(6):331-334.

2. Xihuimin Dai, Enxing Zhou, Wei Yang, Xiaohui Zhang, Wenxia Zhang, and Yi Rao.D-Serine Made by Serine Racemase in Drosophila Intestine Plays a Physiological Role in Sleep, Nature Communications , 2019, 10:1986

3. Deng Bowen, Qi Li, Xinxing Liu,Yue Cao, Bingfeng Li, Yongjun Qian,Rui Xu, Renbo Mao, Enxing Zhou, Wenxia Zhang,Juan Huang, and Yi Rao, Chemoconnectomics: Mapping Chemical Transmission inDrosophila, Neuron,2019,101(1):876-893

4. Biqing Chen, Zijian Zhu, Ren Na, Wan Fang, Wenxia Zhang, Qin Zhou, Shanbi Zhou, Han Lei, Ailong Huang, Tingmei Chen, Dongsheng Ni, Yuping Gu, Jianning Liu, Fang Fang, and Yi Rao. Genomic analyses of visual cognition: perceptual rivalry and top-down control. Journal of Neuroscience ,2018,38(45): 9668-9678

5. Zhang SS, Liu Y, Rao Y , Serotonin signaling in the brain of adult female mice is required for sexual preference , Proc Natl Acad Sci USA , 2013 , 110: 9968-9973

6. Liu WW, Liang XH, Li YN, Gong JX, Yang Z, Zhang YH, Zhang JX and Rao Y , Social regulation of aggression mediated by pheromonal activation of Or65a olfactory receptor neurons in Drosophila , Nature Neurosci , 2011 , 7:896-902 ,

7. Liu Y, Jiang Y, Si Y, Kim J-Y, Chen Z-F, and Rao Y , Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brain of male mice , Nature , 2011 , 472:95-99 ,

8. Zhou C, Rao Y, and Rao Yi , A subset of octopaminergic neurons are important for Drosophila aggression , Nature Neurosci , 2008 , 11:1059-1061 ,

9. Li X, Gao X, Liu G, Xiong W, Wu J, Rao Y , Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling , Nature Neurosci , 2008 , 11:28-35 ,

10. Jiang H, Guo W, Liang XH, and Rao Y , Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3b and its upstream regulators , Cell , 2005 , 120: 123-135 ,

11. Ward ME, Wu JY and Rao Y , Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells , Proc Natl Acad Sci USA , 2004 , 101:970-974 ,

12. Liu G, Beggs H, Jürgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu JY, and Rao Y , Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons , Nature Neurosci , 2004 , 7: 1222-1232 ,

13. Zhu Y, Yu T, Zhang X-C, Nagasawa T, Wu JY, and Rao Y , Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons , Nat Neurosci , 2002 , 5: 719-720 ,

14. Wong K, Ren X-R, Huang Y-Z, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong W-C, and Rao Y , Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway , Cell , 2001 , 107: 209-221 ,

15. Wu JY, Feng L, Park H-T, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Z, Zhang X-C, and Rao Y , Slit, a molecule known to guide axon projection and neuronal migration, inhibits leukocyte chemotaxis induced by chemotactic factors , Nature , 2001 , 410: 948-952

16. Wu W, Wong K, Chen JH, Jiang ZH, Dupuis S, Wu JY, and Rao Y , Directional guidance of neuronal migration in the olfactory system by the protein Slit , Nature , 1999 , 400: 331-336 ,

17. Li HS, Chen JH, Wu W, Fagaly T, Yuan WL, Zhou L, Dupuis S, Jiang Z, Nash W, Gick C, Ornitz D, Wu JY, and Rao Y , Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons , Cell , 1999 , 96: 807-818 ,

18. Zhu Y, Li HS, Zhou L, Wu JY, and Rao Y , Cellular and molecular guidance of GABAergic neuronal migration from an extra-cortical origin to the neocortex , Neuron , 1999 , 23: 473-485

19. Li HS, Tierney C, Wen L, Wu JY and Rao Y , A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm , Development , 1997 , 124: 603-615 ,

20. Rao Y., Jan L.Y., and Jan Y.N. , Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins , Nature , 1990 , 345: 163-167 ,